Reliable in the sense of blowing a tip off? If so... I haven't blown one off yet, but it happens. That's the reality.
If you mean in terms of performance, then just tune them how you want. Expect a little bit of haze to creep up next to the truck if you're stuck in traffic or sitting still for too long and it's chilly out, as it will start wet-stacking a bit. Maybe some people tune this out, but I nullify as much temperature correction as I can for consistency in what my PCM outputs, so I just deal with it.
I actually set my timing to a flat 20 degrees across the entire sea-level and altitude tables yesterday just to see how a mech pump would drive in terms of fixed timing, and this morning I fired the truck in the snow and I swear it smoked less. The smoke was light gray instead of the usual blue. It sounded a little harsh, but seemed to run fine, lol.
Point being, a 400% nozzle can be driven around with good results all day. But you can't F around with the tune. An improper tune and it will not just "be okay" like other nozzles. It will ruin your life and be a total nightmare, lol.
If I weren't planning to exceed 600rwhp, I would run a 200% EDM all day, because they are pretty much the pinnacle of quality, and quantity in terms of riding that fence. The 400 gives up quality for quantity. But... if you need that quantity, you have no choice.