Depending on what your goals are. You may be looking at more transmission work too. Reading your sig, but knowing your goals and what you expect from it and what you want to do with the truck will help us make suggestions.
Myself, I'm running 238/100s, good tuning, a s366sxe, all supporting mods and with a manual transmission, drw, and ~8k weight pulled in 14.9 @ 94 or 95 mph. With an auto I'd be faster. But dragging the truck is not it's main purpose. Towing and cruising is it's primary purpose. I get 16-17 mpg empty @ 65-70 mph. Couldn't be happier with my setup.