While certain injector builders have different ways of building so called "225s", I highly doubt that there is a single HPOP (in and of itself, unless you do some sort of HPODS) out there right now that can hold a solid 4+ volts of ICP with a tune that runs enough PW to fully stroke the injector regardless of who built them. Hybrids don't count unless you want to sacrifice injection pressure.
I would say 205-210cc conventionals (again depending on the injector builder) are about all that a single HPOP can handle and depending on whose truck they're going on would depend on whether that number is too big.
FWIW, Adrian's truck ran about the same as Ivan's with the Adrenaline pump and Warren's 225/75s.