You didn't really say what you are trying to support (larger injectors, etc.) so it's hard to make any kind of real suggestion. If you are doing injectors smaller than 190cc, and not going for all out extreme level tuning, there is no need to upgrade at all.
On the other hand, if you are planning a significant upgrade, there are options. The question then becomes "how are you using the truck"? Daily Driver, family hauler, reliability is important? Competition, second vehicle, performance is most important?