Its pretty easy, but you do have to get a wire harness adapter to go from aftermarket radio to factory wire harness.
like this..... https://www.amazon.com/Metra-70-1771-Harness-Lincoln-1998-Up/dp/B0002BEWZQ/ref=sr_1_1?ie=UTF8&qid=1526487898&sr=8-1&keywords=2004+f250+radio+wiring+harness
also...