I ran 300/100 hybrids on the stock turbo for months in my 550 and it drove great. I now have a 38R in it and it tows very heavy and very hard very often without issue.
Flat to the floor at any GCVW it will not exceed 1200 degrees worse case and it's putting out enough power that I have melted another ZF6 and scorched the fluid in the dana 135. I would estimate that it is between 250 and 350rwhp.
Point is, you can run whatever injector on whatever turbo you want if you simply tune it accordingly. You could run 400/400's with NO turbo and be just fine if you wanted. Might only make 130hp, but it could be made to run like a top if you wanted.