IMHO it is a little more complicated than a HP #. Turbo set up and fueling down low are very important. It seems to me singles can make a lot more HP "safely" cause it doesn't have low RPM torque. Valvetrain will also factor in depending on how fast he plans to spin the engine. I don't work as a mechanic so people like Morgan and other shop owners see a lot more than me, but I can't recall ever seeing the bottom end fail in a non-reman engine that wasn't over-revved, floated a valve from high EBP, or the piston let lose in 750 HP or under application. Do they exist...sure, but in most applications, I would feel safe up 750. In the end, especially in high HP applications, ch#t eventually fails and the more it is abused, the sooner it usually fails.