It's just that this topic always comes up, there's even a sticky on it, gets old hearing the same fuel economy stuff over and over when bottom line is: surface area + speed = bad economy. Honestly at those speeds it doesn't matter what tune you run, wind resistance trump weight. Weight in motion requires very little power to keep going, it's drag and wind resistance that pulls the mileage down.
Now if you're talking huge altitude changes, then yes, a hotter tune will net you better mileage, but you're still not going to see 20mpg, unless you set the cruise to 55mph and like getting honked at or blown off the road by angry truckers.
This is why you're starting to see big rigs with smoother front ends, wheel caps, and skirts/rear deflectors *that crap on the back of reefers that looks like an unfolded cardboard box top*. They're starting to realize aerodynamics and drag effects fuel economy upwards of 3mpg on these rigs. Do the math, that's huge for trucks. Going from 5-6mpg to 8-9mpg on a rig is insane.