Absolutely, the core flows way better and the upgraded intercooler does transfer heat much more efficiently, so although cruising temps may not be affected, under high load the intercooler will absolutely remove more heat as long as the secondary system can remove the heat from the coolant.
Using coolant to remove heat is extremely efficient, a2w intercooling is an extremely efficient process but using air to remove heat in the heat exchanger is far less efficient.
It may not be as apparent on a stock truck but I can tell you that NL CAC is a big improvement when you start getting into aftermarket chargers and fueling upgrades.
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