My limited experience for your research. I have 175k on my 6.0 at the moment and no fears of driving it anywhere with these miles, only making 400hp, just your typical tuned truck. I bought it with 49k on it, tuned (Innovatives Xtreme race) at 73k, always had a winter cold start issue (never plugged in, always eventually started on its own) that finally got remidied with 6 injectors at 92k, finally blew the top end at 113k, studded, new heads, oil cooler, delete, etc. Basically I am happy, go pedal usually touches the floor at least once every time I drive it, it's run down the strip maybe 30 times, tow up to 10k on the race tune and just drive it.
If you get that truck and fully expect to do that work at some point or another you should be fine.