We made some changes..
swapped from the stock turbos to a compound setup we fabricated...S366 high pressure, S475 low pressure. both wastegated (externally).
also installed our ported intake manifold, and some other parts inconsequential to this discussion. (fire ringed heads, studs, springs, pushrods)..
but we kept the injs/HPCR pump untouched (stock)
mileage increased 2.5mpg...and that was with some pretty heavy beating on it (maybe one or two 50-100+mph bursts each day..in addition to a couple of hours on a chassis dyno, which showed 90hp increase over stock chargers, btw @ 630rwhp).
I know this isn't anything near an ideal 'back to back' comparison...but the lack of boost on extended highway driving (no VG)...has GOT to be the main factor in the significant increase in mpg...
we won't be doing any more 'mpg' friendly modifications to this truck..but I'll update should the numbers change significantly with any future modification.