Just resealed the up pipes on my E99, pitched the non-compressible junk 8194 Fel Pro donuts everyone raved about that leaked like crazy, and passed on the graphite Mahle/Victor F17250 donuts in favor of a pristine set of used Ford seals. Cleaned up the pipes really nicely, replaced the drivers side with a shortened L99 pipe, the passenger pipes are not even remotely similar angles, so I just dressed it nicely and ran with it for now.
What an effing difference in spool up and power. If the throttle response is sluggish, chances are good you've got leaking up pipes. And if you do, you're using more throttle, and that's how you're managing the lousy fuel mileage. I went from 19mpg tuned with the stock turbo on 285/75-16s with 3.73s to 16mpg lifted on 35s, to 15mpg with the D66 (and apparently a small up pipe leak) to 13mpg when I installed the 37s to 12mpg, and then 11mpg at which point I snugged up the flanges best I could, back to 13mpg. All the while, EGTs were getting harder to manage, power was fading, and throttle response was becoming more sluggish. EGTs are down where they belong again, throttle response is snappy, and the turbo starts to spool at 1300rpm instead of 2000rpm, I expect the next tank will see an improvement back into the 15+mpg range once I lay off the skinny pedal.
Now, I did have an '01 F550 with a service bed that weighed in at close to 22k at my last job that had 285k on it, with 4.88s and 225-70-19.5s thats like driving a truck with 3.73 everywhere with the overdrive turned off, and those 285k miles were equivalent to close to 400k because of the rpm that old girl turned everywhere she went going 68-70mph. I did a turbo overhaul, bellowed pipes, new IC boots, and finally injectors on that truck because it got to the point it would barely start. It went from 8mpg to 12mpg, power was way better, and you didn't have to drive it nearly as hard after all the freshening up.
So depending on miles, prior service, and possibly older repairs you're not aware of, you may have some work to do to get this dialed in, but unless its just tired or wounded you should be able to get into the 13-15 range mentioned earlier, maybe a little better still, even with the aerodynamics of a brick lifted 10" on 40s.