Is this a cab&chassis truck?
the F350/450/550 C&C's with the rear mounted (steel) fuel tank have a major issue with the inside of the fuel tank delaminating.
we install (sell & recommend) Titan polyethylene tanks for C&C trucks which are having this issue.
Years ago, we tried pre pump filtration, auxiliary post pump filtration...but the tank(s) would delaminate so fast that the trucks would continue clogging the filters and running around w/ zero fuel pressure damaging injectors (again).
It's a big investment (the Titan tank)...however it's cheaper than replacing set after set of injectors due to lack of pressure/flow/contaminants.
also note that we've seen C&C trucks have issues with flow from the bowl to the head(s) even after the tank is replaced (and lines purged), due to the fittings in the head(s) which have the inlet screen.
The fitting which is adapts the fuel lines to the heads should also be removed, cleaned/replaced as necessary to ensure fuel pressure at the bowl is actually getting to the cyl heads.