For 6.5's I honestly don't think you would have to trim anything. Worst case though, you might have to remove about 1/8" to a 1/4" of material on 2 sides of the factor openings in the door. OR... you could get some 1/2" MDF or HDPE (cutting boards) and make some adapter rings, these will also space the speaker out from the door a 1/2" which should make it fit without any problems.
the factory openings are 6"x8" (nominal) and the cutout diameter of these 6.5"
example speakers is 4-15/16" which should fit without any modifications. I am thinking back, and I believe the opening at the narrowest is 5.5" across.