I am running the 87 mm S475 with a 1.10 housing and I have no complaints about it. With the singles IMO it all comes down to tuning. The O/D is the primary culprit when daily driving. I was running erics x-street with the delay loc tune and I was able to hold the O/D off till 60 mph. For me the turbos really start to light good around 70mph, so as you can see that range between 60-70 mph will cause the turbo to fall on its face.
What are your overall goals with the single? If your looking for power then the S475 kit will work best for you. With the right mixture of fuel and MPD's kit you can be close to or at 900 HP easily.
As far as MPG goes I average around 19-20 hand calculated. When cruising around 75 mph on the highway RPM's are below 2 grand and boost is around 3 PSI.
I did tow my 6,000 lb boat a few times and it did pretty well. The time it takes to build boost on these singles is pretty rough when towing and I had to baby it till I built boost up. You can definitely tow pretty small loads but nothing to crazy.
Overall I am in love with this setup. I have about 700 miles on it so far with zero issues. I am working on getting custom tunes from Mike@KEM which I can cancel the O/D with using the tow/haul button. If the O/D is canceled like it states, I will have zero problems or regrets in running the setup.