Finally ran the better part of a tank on my 6.0L and with the Hercules tune and Extreme ECM tune I went 289 miles on 14.16 gallons of fuel, for an average of 20.41 MPG. That is filling at the same station, same pump, same angle, and filled to the neck. My previous tank (which I only ran a little bit) was 139 miles on 7.04 gallons of fuel for an average of 19.74 MPG. Not bad for a truck that makes 442 HP! For reference, the best I have ever recorded prior to that was in the 17.9 MPG range.
Now keep in mind my truck is a 2WD Single Cab on street tires at 65-70 PSI. I was also driving like I had my grandmother in the truck. I'm going to try a tank on "normal" driving and see where I end up. So far though, I'm pretty happy where I'm at.
Hopefully we'll get some other results posted in here. I'm curious as to what the lifted trucks are getting.