With larger nozzles there can be some things you might have to sacrifice. For me, fuel mileage stayed the same, but here's some things to consider:
One for certain is cold start white smoke in the winter. That's just a given. You can reduce it with tuning up to a point, but it's always going to blow more white smoke in the dead of winter on a cold morning than a truck with much smaller nozzles. Not a big deal for me at least, I went from a medium amount of white smoke to a larger amount. Still smells like crap, and still pisses the neighbors off just the same I'm sure. Although it's never once made yellow snow like the stock injectors did. Still trying to figure that one out.
Idle quality is another. It can be a bit tricky getting it to idle smooth as glass. Then you get it smoothed out, a 4 hour road trip returning to idle gets a bit of a chop that comes right back again.
But really the main thing is getting the tuning dialed in to a safe level. It really doesn't take much at all to dump a lot of fuel in a hurry. So pick a good tuner and make sure you let them know exactly what you are trying to accomplish.
That being said, there is no guarantee that something won't break. They are PMR's after all.